USMLE (Fach) / Pharmacology - Immunology (Lektion)

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• Cetuximab Target: EGFR Clinical use: - Stage IV colorectal cancer- Head and neck cancer
• Rituximab Target: CD20 Clinical use: - B-cell non-Hodgkin lymphoma- CLL- Rheumatoid arthritis- ITP- Multiple sclerosis
• Trastuzumab Target: HER2/neu Clinical use: - Breast cancer- Gastric cancer
• Bevacizumab Target: VEGF Clinical use: - Colorectal cacer- Renal cell carcinoma- Non-small cell lung cancerOcular:- Neovascular age-related macular degeneration- Proliferative diabetic retinopathy- Macular edema
• Alemtuzumab Target: CD52 Clinical use: CLL, multiple sclerosis
• Cyclosporine Calcineurin inhibitor, binds cyclophilin.Blocks T-cell activation by preventing IL-2 transcription. Use:- Psoriasis- Rheumatoid arthritis Toxicity:- Nephrotoxicity- Hypertension- Hyperlipidemia- Neurotoxicity- ...
• Tacrolimus (FK506) Calcineurin inhibitor (like cyclosporine), binds FK506 binding protein.Blocks T-cell activation by preventing IL-2 transcription.  Use: Transplant rejection prophylaxis Toxicity: Similar to cyclosporine ...
• Sirolimus (Rapamycin) mTOR inhibitor; binds FKBP.Blocks T-cell activation by preventing response to IL-2.Synergistic with cyclosporine. Use: - Kidney transplant rejection prophylaxis specifically- Drug-eluting stents Toxicity:- ...
• Azathioprine Antimetabolite of precursor of 6-mercaptopurine.Inhibits lymphocyte proliferation by blocking nucleotide synthesis. Use:- Rheumatoid arthritis- Crohn disease- Glomerulonephritis- Other autoimmune conditions ...
• TNF-α inhibitors Adalimumab, certolizumab, golimumab, infliximab Clinical use:- IBD- Rheumatoid arthritis- Ankylosing spondylitis- Psoriasis - Etanercept is a decoy TNF-α receptor and not a monoclonal antibody
• Basiliximab Monocloncal antibody; blocks IL-2 receptor. Use: Kidney transplant rejection prophylaxis Adverse effects:- Edema- Hypertension- Tremor
• Mycophenolate mofentil Reversibly inhibits IMP dehydrogenase, preventing purine synthesis of B and T cells. Use: - Lupus nephritis- Used in combination with cyclosporin or tacrolimus as transplant rejectionprophylaxis Adverse ...
• Aldesleukin Interleukin-2 Clinical use:- Renal cell carcinoma- Metastatic melanoma
• Interferon-α Clinical use:- Chronic hepatitis C and B- Renal cell carcinoma
• Interferon-β Clinical use:- Multiple sclerosis
• Interferon-γ Clinical use:- Chronic granulomatous disease
• Daclizumab Target: CD25 (part of IL-2 recptor) Clinical use:- Relapsing multiple sclerosis
• Eculizumab Target: Complement protein C5 Clinical use:- Paroxysmal nocturnal hemoglobulinuria
• Natalizumab α4-integrin Clinical use:- Multiple sclerosis- Crohn disease - α4-integrin: WBC adhesion- Risk of PML in patients with JC-virus
• Ustekinumab Target: IL-12/IL-23 Clinical use:- Psoriasis- Psoriatic arthritis
• Abciximab Target: Platelet glycoproteins IIb/IIIa Clinical use: Antiplatelet agent for prevention of ischemic complications in patients undergoing percutaneous coronary intervention
• Denosumab Target: RANKL Clinical use:- Osteoporosis; inhibits osteoclast maturation (mimics osteoprotegerin)
• Omalizumab Target: IgE Clinical use: Refractory allergic asthma; prevents IgE binding to FcεR
• Palivizumab Target: RSV F protein Clinical use: RSV prophylaxis for high-risk infants
• Glucocorticoids Inhibit NF-κB. Suppress both B- and T-cell function by ↓ transcription of many cytokines.Induce T cell apoptosis. Use:- Many autoimmune and inflammatory disorders- Adrenal insufficiency- Asthma- CLL, ...
• Colony stimulating factors Filgrastim (G-CSF)Sargramostim (GM-CSF) Clinical uses:- Leukopenia- Recovery of granulocyte and monocyte counts
• Thrombopoietin Romiplostim (TPO analog)Eltrombopag (TPO receptor agonist) Clinical use:- Autoimmune thrombocytopenia

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