10
Developmental Biology (Subject) / Lecture 1 (Lesson)
- What describes Developmental Biology? development, embryogenesis, regeneration, metamorphosis
- function of seam cell/stem cell maintain stem cell lineage and differentiate into specific cell types
- why is a seam cell not a true stem cell? it terminally differentiates in the end of c.elegans life cycle
- how can cells be polarised? by an intrinsic organisation of cellular signals
- symmetric breaking initiation of polarity: after fertilisation, Rho-mediated cytoskeleton rearrangement
- anterior par-proteins par-3 and 6
- posterior par-proteins par-1 and 2
- male drosophila germ niche 9 GSCs -> surrounded by cyst progenitor cells -> assymmetric division -> gonialblasts -> sperm maintainance of stem cell lineage: JAK-STAT pathway
- female drosophila germ niche GSC -> assymmetric division -> cytoblast -> differentiation -> increase of cysts towards the posterior maintainance of stem cell lineage: Dpp -> TGFβ -> represses bag of marbles transcription factor
- pathway of an asymmetric division symmetry breaking -> polarity establishment, determinant segregation -> spindle positioning -> two different daughter cells
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