Pharmacology - CNS

MAO inhbitor - irreversible inhibition of MAOA and MAOB Use: atypical depressions Drug interactions- serotonin syndrome- ↑ NE: hypertensive crisis

Antidepressant - dopamine reuptake blocker - used in smoking cessation

- DOC for bipolar disorders - usually antidepressants/antipsychotics also required - prevents recycling of inositol (↓PIP2) by blocking inositol monophosphatase- ↓ cAMP Side effects:- narrow therapeutic index; requires therapeutic monitoring- tremor, flu-like symptoms, life-threatening seizures- hypothyroidism with goiter- nephrogenic diabetes insipidus (↓ADH effect)

- amphetamine-like - Used in ADHD Side effects:- agitation- restlessness- insomnia- cardiovascular toxicity

- SNRI Used in ADHD

Barbiturate - prolonges GABA activity with GABA mimetic activity at high doses - used for seizures