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Virology (MD PhD) (Subject) / Henni (Lesson)

Henni

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  • ONYX-015 or H101 Deletion of E1B-55K ➔ cannot inhibit p53 ➔ virus is attenuated in normal cells - in cells that are p53 deficient (cancer cells!) --> virus can replicate - head and neck cancer treatment combined with chemotherapy

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