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Viva (Subject) / Platelet function (Lesson)
- GPIa/IIa, GPVI and probably GPIV engaged in platelet adhesion to collagen.
- GPIb-V-IX complex first critical step in platelet adhesion, binds vWF, GPIb-IX-V consists of four different subunits namely: GPIbα, GPIbβ, GPIX and GPV The GPIbα subunit bears the binding site for von Willebrand factor (vWF), α-thrombin, leukocyte integrin αMβ2 and P-selectin. The binding between GPIbα and vWF mediates the capture of platelets to the injured vascular wall.
- GPVI glycoprotein It is an important collagen receptor involved in collagen-induced platelet activation and adhesion. It plays a key role in their procoagulant activity and subsequent thrombin and fibrin formation
- GPIa / IIa glycoproteins integrin α2β1, This is a receptor for collagen type I and IV
- GPIIb / IIIa glycoproteins integrin αIIbβ3, This complex interacts with fibrinogen and thus plays an important role in platelet aggregation and adhesion to endothelial surfaces
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