Pharmakologie / Lesson
Cornell Heme/Onc
19 Cards · This lesson was created by estoffel.
Cornell
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- ZosynPiperacillin/Tazobactam Use:- Neutropenic fever
- AtroventIpratropium
- Prophylaxis during chemotherapyValacyclovir (Valtrex), Psaconazole
- VenetoclaxBcl-2 inhibitor Use:- CLL with 17p mutation or relapse Adverse effects:- Tumor lysis syndrome- Neutropenia, thrombocytopenia
- DecitabineHypomethylating agent, Cytidine analog Use:- AML- Myelodysplastic syndromes
- VelcadeBortezomib Proteosome inhibitor Use:- Relapsed multiple myeloma and mantel cell lymphoma
- DaratumumabCD38 inhibitor (overexpressed by multiple myeloma cells)
- RevlimidLenalidomide Use:- Multiple myeloma- Mantel cell lymphoma- Deletion 5q myelodysplastic syndrome
- DilaudidHydromorphine hydrochloride
- KeflexCefalexin 1st generation cephalosporine
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- MidostaurinMulti-targeted protein kinase inhibitor Use:- AML positive for FLT3- MDS
- ClofarabinePurine nucleotide antimetabolite Use:- ALL- AML- Bridge to hematopoietic stem cell transplant
- JakafiRuxolitinib JAK1/2 kinase inhibitor Use:- Myelofibrosis- Polycythemia vera unresponsive to hydroxyurea- Pretreatment of BMT to shrink spleen
- SevelamerPhosphate binding drug Use:- Hyperphosphatemia in patients with CKD
- VyxeousCytarabine and daunorubicin 7+3 Use- t-AML- AML-MRC (myelodysplasia related changes)
- NeoralCyclosporine
- Actinium-LintuzumabTargets CD33 Use:- Older patients with previously untreated AML unfit for chemotherapy
- SorafenibTyrosine protein kinase inhibitor (VEGF, PDGFR, Raf family kinases) Use:- Renal cell carcinoma- Unresectable HCC- Thyroid cancer- AML (FLT3-ITD+)
- NilotinibTyrosine kinase inhibitor Use:- Imatinib-resistant CML