Pharmakologie / Lesson

Cornell Heme/Onc

19 Cards · This lesson was created by estoffel.

Cornell

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  • Zosyn
    Piperacillin/Tazobactam  Use:- Neutropenic fever
  • Atrovent
    Ipratropium
  • Prophylaxis during chemotherapy
    Valacyclovir (Valtrex), Psaconazole
  • Venetoclax
    Bcl-2 inhibitor Use:- CLL with 17p mutation or relapse Adverse effects:- Tumor lysis syndrome- Neutropenia, thrombocytopenia
  • Decitabine
    Hypomethylating agent, Cytidine analog Use:- AML- Myelodysplastic syndromes
  • Velcade
    Bortezomib Proteosome inhibitor Use:- Relapsed multiple myeloma and mantel cell lymphoma
  • Daratumumab
    CD38 inhibitor (overexpressed by multiple myeloma cells)
  • Revlimid
    Lenalidomide Use:- Multiple myeloma- Mantel cell lymphoma- Deletion 5q myelodysplastic syndrome
  • Dilaudid
    Hydromorphine hydrochloride
  • Keflex
    Cefalexin 1st generation cephalosporine
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  • Midostaurin
    Multi-targeted protein kinase inhibitor Use:- AML positive for FLT3- MDS
  • Clofarabine
    Purine nucleotide antimetabolite Use:- ALL- AML- Bridge to hematopoietic stem cell transplant
  • Jakafi
    Ruxolitinib JAK1/2 kinase inhibitor Use:- Myelofibrosis- Polycythemia vera unresponsive to hydroxyurea- Pretreatment of BMT to shrink spleen
  • Sevelamer
    Phosphate binding drug Use:- Hyperphosphatemia in patients with CKD
  • Vyxeous
    Cytarabine and daunorubicin 7+3 Use- t-AML- AML-MRC (myelodysplasia related changes)
  • Neoral
    Cyclosporine
  • Actinium-Lintuzumab
    Targets CD33 Use:- Older patients with previously untreated AML unfit for chemotherapy
  • Sorafenib
    Tyrosine protein kinase inhibitor (VEGF, PDGFR, Raf family kinases) Use:- Renal cell carcinoma- Unresectable HCC- Thyroid cancer- AML (FLT3-ITD+)
  • Nilotinib
    Tyrosine kinase inhibitor Use:- Imatinib-resistant CML