USMLE (Fach) / Pharmacology - Cardiovascular (Lektion)
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Hypertensive emergency
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Treat with clevidipine, fenoldopam, labetalol, nicardipine, or nitroprusside.
Nitroprusside: Short acting; ↑ cGMP via direct release of NO. Can cause cyanide toxicity (releases cyanide).
Fenoldopam: Dopamine D1 receptor agonist – coronary, peripheral, renal, and splanchnic vasodilation. ↓ BP, ↑ natriuresis. Also used postoperatively as an antihypertensive. Can cause hypotension and tachycardia.
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