Primary (essential) hypertension: Thiazide diuretics, ACE inhibitors, angiotensin II receptor blockers (ARBs), dihydropyridine Ca²⁺ channel blockers.

Hypertension with heart failure: Diuretics, ACE inhibitors/ARBs, β-blockers, aldosterone antagonists.- β-blockers are contraindicated in cardiogenic shock.- In HF, ARBs may be combined with the neprilysin inhibitor sacubitril.

Hypertension with diabetes mellitus: ACE inhibitors/ARBs, Ca²⁺ channel blockers, thiazide diuretics, β-blockers- ACE inhibitors/ARBs are protective against diabetic nephropathy.

Hypertension in pregnancy: Hydralazine, labetalol, methyldopa, nifedipine

Hypertension in asthma: ARBs, Ca²⁺ channel blocks, thiazide diuretics, selective β-blockers.- Avoid nonselective β-blockers to prevent β₂-receptor-induced bronchoconstriction. Avoid ACE inhibitors to prevent confusion between drug or asthma-related cough.