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- How does vascular endothelial growth factor (VEGF) act on endothelial cells? VEGF bind to surface membrane receoptors of endothelia cells (VEGFR)
- Which transcription factor is induced upon hypoxia in tumor cells? VEGF
- How can tumor angiogenesis be inhibited? Antibodies against VEGF-A : Ranibizumab (Lucentis®) VEGF-Trap (Aflibercept®) Bevacizumab (Avastin®) Antibody against VEGFR-2 : Ramucirumab (Cyramza®) Inhibitors of Receptor- Tyrosinekinase-Activity: Sunitinib (Sutent®) Sorafenib (Nexavar®)
- Which organelles are specific for endothelial cells? vesiculo-vacuolar organelle (VVO)
- Which gateways are used by tumor cells to metastasize? lymph and blood vessels.
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