Biochemistry (Subject) / Nucleic acids (Lesson)

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• purines adenine, guanine
• pyrimides cytosine, tymine (and urazil)
• purine biosynthesis from ribose-5-phosphate transferred ti inosine monophosphate (needs 7ATP) AMP and GMP are synthesized from IMP
• purine catabolism hydrolysis of nucleosides, the free base is further degraded tu uric aced in humans (further in other animals) GMP is converted to xanthine AMP via inosine to hypoxanthine to xanthine xanthine will be converted to uric acid further converted to allantoine in terrestrial animals
• Pyrimidine synthesis ring is assembled before it is attached to ribose-5-phosphate carbomyl-Asp as intermediate, forming UMP, which is the precursor of both Pyrimidines
• pyrimidine catabolism reults in non-proteiniogenic ß-amino acids cytosine -> ß-alanine Thymine -> ß-aminoisobutyric acid

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