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Onko (Subject) / 3. Manzl (Lesson)
- Molekulare Targets von Rituximab / Mode of action / Anwendungsbereich Antibody against CD20 / selective depletion of CD20+ cells via apoptosis, complement mediated B-cell lysis, AB dependent cellular toxicity / B-cell non hodgkin lymphomas, transplantation associated lymphomas (PTLD)
- Grundprinzip & Anwendungsbeispiele für FISH Analysen Anwendungsbeispiele: Pränataldiagnostik, Krebsdiagnostik, Targeted Therapy Probe DNA with a specific sequence, labeled with fluorescence dye, enters the nucleus and hybridizes to its complementary DNA sequencel
- Bedeutung der HER2 Amplifikation 20% of breast cancers, allows targeted diagnosis and therapy HER-2 is a membrane tyrosine kinase, after heterodimerization HER-2 activates key signaling pathways like PI3K/AKT which can induce cell proliferation, survival, differentiation, angiogenesis, invasion and metastasis