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Medical Microbiology (Subject) / Cardiovascular & Lymphatic system (Lesson)
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- Lymphatics transport interstitial fluid to heart
- Lymph nodes contain fixed macrophages
- ANTRHAX Bacillus anthracis Zoonotic disease / spores in ground causes septic shock
- Antrhax (cutaneous) 95% of human cases spores enter broken skin / 1-12 days incubation forms necrotic black ulcer 20% mortalilty without antibio <1% with antibio
- Anthrax (inhalational) hemorrhagic infection of lymph nodes within 2-3 days respiratory failure 100% mortality
- Anthrax (gastrointestinal) ingestion of infected meat intestinal eschar 1-7 days / 25-60% mortality
- Anthrax (capsule) D-glucamic acid (antiphagocytotic) not a good immunogen
- Anthrax (Toxin) AB toxin two A subunits Edema factor: adenylcyclase (water eflux) Lethal factor: protease MAP kinase cleaved (necrosis follows)
- THE PLAGUE Yersinia Pestis / pleomorphic rod buboes: swollen hemorrhagic lymph nodes sepsis: subcutenous hemorrhagy pneumonic: dead within 24h
- Lyme Disease Boreliose Borelia burgdorferi (spirochete) spread by ticks
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- Lyme Disease (stages) Stage 1) Erythema migrans ring stage 2) spirochetes cause immune system to overclock (fever,fatique) Stage 3) Arhtritis
- Lyme Disease (treatment) vaccine vs protein A eff: 78% but taken from market better not get bitten by ticks