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antibiotics (Subject) / Pleuromutilins (Lesson)

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• active substances - Valnemulin - Tiamulin
• Mechanism, Mode of action Mechanism: inhibition of protein synthesis (50S) Mode: bacteriostatic
• absorption good PO, can also be given IM
• distribution excellent
• metabolism liver -> inhibit CYP450 -> don't combine with ionophore drugs (chicken get ionophores their whole life)
• excretion bile urine, only metabolites -> cannot be used in UTI
• side effects very safe irritative urinary metabolite can cause irritations, eg. vulvar edema
• microbial spectrum Gr+ pleuromutilins are the best drugs to use in the world against... - Brachyspira hyodysenteriae - Lawsonia intracellularis - Mycoplasma respiratory tract infections: - tiamulin: mycoplasma +++, fasti. + - valnemulin: mycoplasma ++++, fasti. +++

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