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antibiotics (Subject) / Lincosamides (Lesson)

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• Mechanism, Mode of action Mechanism: Inhibition of protein synthesis (50S) Mode: bacteriostatic
• pharmacokinetics absorption: good distribution: excellent -> IC & special barriers high metabolism in liver excretion: bile & urine (in urine only metabolites -> not for UTI)
• microbial spectrum - Gr+ - anaerobs (Foot diseases, Bite wounds etc.) - R. equi -> BUT DON'T treat horses with lincosamides - NOT for fastidious organisms, except: Brachyspira h., Lawsonia i., Mycoplasma, Campylobacter
• Indications IC-microorganisms bone-infections
• side effects - severe tissue irritations -> no application via injection - dysbacteriosis -> leads to life-threatening colitis (strictly forbidden in horses, herbivore-rodents)
• active substances - lincomycin - clindamycin
• Lincomycin - used in food-producing animals - foot diseases (anaerobs) - wounds, mastitis, metrtitis (Gr+ cocci) - swine dysentery (Brachyspira h.) (tylvalosin and tylosin are also good) - respiratory infections (mycoplasma +++, fasti. -) -> synergistic combo with spectinomycin (aminoglycoside) 
• Clindamycin - used in small animals - dermatitis, abscesses (Gr+ cocci) - oral cavitiy infections (anaerobs) - osteomyelitis - campylobacter

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