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Bakteriologie (Subject) / Bacillus, Clostridien (Lesson)
- C. perfringens in pigs C --> necrotic enteritis
- C. colinum in quail, chicken, turkey, pheasant ulcerative enteritis intestinal ulceration hepatic necrosis
- C. difficile in humans, foal and dogs = enterotoxin, cytotoxin human: pseudomembranaceus colitis foal: haemorrhagigc enterocolitis in newborn foals dog: chronic diarrhea
- C. tetani strict anaerobic --> there are 10 serotypes (on the basis of flagella antigenes) --> same toxin effect toxins: - neurotoxin (tetanospasmin: inhibits Ach-esterase --> ach goes up --> rigid paralysis) - haemolysin - fibrinolysin
- C. tetani --> Tetanus horses, men: highly susceptible ruminants, pigs: moderately susceptible carnivores: comparatively resistent poultry: not susceptible
- C. botulinum biochemically not uniform ABEF antigens: soil, activated by trypsin, human diseases CD: soil, intestines, animal diseases toxins: inhibit release of Ach in neuromuscular synapsis heat stabile, 100°C for 20 minutes
- C. piliforme gram variable culture: mouse fibroblast, liver, embryonated egg disease: Tizzers disease in dog, cat, foal, rabbit
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