Pathology & Physiology (Subject) / PIPs (Lesson)

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• Def. aetiology & pathogenesis Aetiology = the underlying cause of a disease Pathogenesis = the mechanism by which the aetiology interacts with the cells and organs of the body to produce disease 
• Aetiological factors (2) 1. Genetic - die to an abnormality of the genome (mostly inherited) 2. Acquired - due to factors in the environment   --> Both factors often combined (schizophrenia, high blood pressure)
• Congenital disease - diseases one is born with  - can be inherited or non-genetic (acquired due to environmental factors acting before birth) --> e.g. congenital rubella syndrome
• Occupational diseases - aetiology is related to an individual's occupation --> e.g. repetitive strain injury, trauma, skin rash, lung disease

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