Reversibly inhibits IMP dehydrogenase, preventing purine synthesis of B and T cells.

Use: - Lupus nephritis- Used in combination with cyclosporin or tacrolimus as transplant rejectionprophylaxis

Adverse effects:- GI upset- Pancytopenia- Hypertension- Hyperglycemia, hypercholesterolemia- Elevated BUN- Peripheral edema- Less nephrotoxic and neurotoxic

- Associated with invasive CMV infection