Intrinsic pathway coagulation defect (↑ PTT).A: deficiency of factor VIII → X-linked recessiveB: deficiency of factor IX → X-linked recessiveC: deficiency of factor XI → autosomal recessive- Normal bleeding time (no inherent platelet disorder)

Hemorrhage in hemophilia – hemarthroses (bleeding into joints, eg, knee), easy bruising, bleeding after trauma or surgery (eg, dental procedures).

Treatment: desmopressin + factor VIII concentrate (A), factor IX concentrate (B), factor XI concentrate (C).