USMLE (Fach) / Hematology and Oncology (Lektion)

Vorderseite Coagulation tests
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PT – tests function of common and extrinsic pathway (factors VII, X, V, II, I).

INR (international normalized ratio) – calculated from PT. 1 = normal, >1 = prolonged. Most common test used to follow patients on warfarin.

PTT – tests function of common and intrinsic pathway (all factors except VII and XIII).

Coagulation disorders can be due to clotting factor deficiencies or acquired inhibitors. Diagnosed with a mixing study, in which normal plasma is added to patient's plasma. Clotting factor deficiencies should correct (the PT or PTT returns to within the appropriate normal range), whereas factor inhibitors will not correct.

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