Malaria – fever, headache, anemia, splenomegaly, GI symptoms

P. vivax/ovale – 48-hour cycle, dormant form (hypnozoite) in liverP. falciparum – severe, irregular fever patterns; parasitized RBCs occlude capillaries in brain (cerebral malaria), kidneys, lungs P. malariae – 72-hour cycle

- Transmission: Anopheles mosquito

Diagnosis: - Thick and thin blood smear: trophozoite ring form within RBC, schizont containing merozoites- Red granules (Schüffner stippling) throughout RBC cytoplasm seen with P vivax/ovale

Treatment: - Chloroquine (blocks Plasmodium heme polymerase).- If resistant, use mefloquine or atovaquone/proguanil. - If life-threatening, use intravenous quinidine or artesunate (test for G6PD deficiency).- For P vivax/ovale, add primaquine for hypnozoite (test for G6PD deficiency).