8
Developmental Biology (Fach) / Lecture 3 (Lektion)
- Planar cell polarity:deffinition and example polarizes cells within a field of cells Wnt signaling regulates PCP (pcp mutants show disordered planar polarity)
- Planar cell polarity: mechanism asymmetric distribution of core factors Vang-pk on proximal side of cell Fz, Dsh, Deigo localize distally Flamingo (Fmi) fz and vang signal between cells
- Planar Cell Polarity: more examples embryo cell migration neurulation orientated cell division cilia function left-right in embryo and more!
- Cell-Cell-Contact: Adherence junctions anchoring between cells catenins bound to actin in the cell cadherins are transmembrane proteins between cells and bound to catenins
- Cell-Cell-Contact: Tight Junctions seals intercellular space role in polarity, differentiation and proliferation barrier to cell migration network of claudins
- Cell-cell-contact: Gap Junctions 1-2nm to allow passage of ions and small molecules made up off connexins
- Apical Junctions: DLG-1 essential for DLG-1/AJM-1 complex at epithelial junctions DLG-1 is homolog to Dosophila Discs Large : localizes apical and adherens junctions and regulates cell proliferation dlg-1 mutants lose cell polarity
- Where can you use Dev.bio? Genetics Proteomics Cancer Regeneration Immunology Neurobiology
Anzeige