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Onko (Fach) / 1. Concin (Lektion)
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- Molekularbiologisch basierte Einteilung des Ovarialkarzinoms Type 1: K-RAS,B-RAF, PTEN, beta-catenin: slow growing, early stage,(low-grade serous,low grade endometrious mucinous), precursours : borderline Type 2: p53 genetic instability, highly aggressive, evolve rapidly, high metastatic ability, advanced stage (HGS responsible of 85% death of all ovarian cancer), none precursor
- Was beschreibt der Begriff STIC Serous Tubal intraepithelial carcinoma → Precursor for invasive serous carcinoma after acquiring p53 signature. = early lesion limited to the epithelium of the fallopian tube
- Gemeinsamkeiten und Unterschiede in der p53 Familie p73: inhibition does not cause cancer; tumour specific overexpression in tumours; no cancer phenotype in KO mice Full length p73: Cell cycle arrest+apoptosis, p53 independent → putative tumour suppressive function N-Terminal shorter isoforms: Dominan Inhibition of the oncoprotein function negative inhibition of p53 and p73 → oncogenetic potential p53: Induces apoptosis after DNA damage, mutated in 50% of all human cancers
- Bedeutung/Eigenschaften von Gain-of-Function Mutationen in der p53 Familie Requirement: abberant accumulations Properties: show a broader tumor spectrum including adenocarcinomashigher tumor bulk,grade and invasionnewly gained metastatic abilitymutp53 cancers develop a strong dependency on high levels of mutP53 for survival
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