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IMCH (Fach) / IMCH (Lektion)
- Difference of Response time innate/adaptive Innate: hours adaptive: days
- Difference of specificity innate/adaptive innate: limited and fixed adaptive: highly diverse, improves during course of immune response
- Difference of Response to repeat infection innate/adaptive innate: identical to primary response adaptive: much more rapid than primary response
- Difference of Major Components innate/adaptive innate: Barriers (skin), phagocytes, pattern recognition molecules adaptive: Lymphoxytes, antigen-specific receptors, antibodies
- innate mechanisms of organ or tissue skin: antimicrobial peptides, fatty acids in sebum mouth: Enzymes, antimic. peptides, fluid flow stomach: low pH, digestive enzymes antim. peptides, fluid flow small intestine; digestive enzymes, antimic. peptides, fluid flow large intestine: normal intestinal flora copete with invading microbes airways lungs: cilia sweep mucus outward, coughing, sneezing... urogenital tract: flushing by urine, low pH, antimicrobial peptides salivary: flushing by secretions, antim. peptides in vaginal secretions
- cells of innate immune system and functions: neutrophils: phagocytosis, antimic.peptides macrophages: phagocytosis, inflammatory mediators, antigen presentation cytokines, complement proteins dendritic cells: antigen presentation, costimulatory signals, interferon, cytokines natural killer cells: lysis of viral-infected cells, interferon, macrophage activation
- what is immunochemistry? The chemistry of immunologic phenomena, as of antigen-antibody reactions
- what is affinity? binding strength between a partope of an antibody with an epitope of an antigen
- what is avidity? combined strength of multiple bond interactions with several epitopes.
- Reaction of Ab -Ag 3 phases 1 Ag paratope +1 binding site Ab --> prim. Complex n=1 Prim. Complexes --> aggregates n> 1 Inclusion in precipitates (irreversibel) nAg + nAB <--> nAg-Ab --> (Ag-Ab)n
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