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BIOC2 (Fach) / Energy of Glucose (Lektion)

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• glucose metabolism glucose    -- glycoyse -> Pyruvate          gluconeogenese (back)   glycogeen --glycogenolyse-> glucose    glyconeogenese (back)
• glucose catabolism Glucose glycolisis 2 pyruvate--------------> alternativ 2 Lactate 2 Acetyl-CoA citric acid cycle 4Co2 + 4 H2o
• Glycolysis Phase 1: Glucose + 1 ATP --> glucose-6-phospahte + ADP + H+ by hexokinase Fructose 6-phosphate + 1 ATP --> fruc.1,6-bisphosph. + ADP + H+  by phosphofructokinase-1 2 Glyceraldehyde 3- phophate (GAP)
• Glycolysis phase 2: 2x GAP + NAD+ --> 1,3-bisposphoglycerate + NADH + H+ by glyceraldehyde 3-phophate dehydrogenase 1,3 bisphosphoglycerate + ADP --> 3 phosphoglycerate + ATP by phosphoglycerate kinase ..... phosphoenolpyruvate+ ADP + H+ --> Pyruvate + ATP by pyruvate kinase
• Verbindung zwischen glycolysis and citric acid cyle Transportation by carrier into matrix and: pyruvate (C3) + CoA + NAD+ ---> Acetyl-CoA (C2)+ CO2 + NADH +H+ by pyruvate dehydrgenase
• Principe of citric acid cycle: C2 + C4 = C6 --> C5--> C4
• controlpoints in citric acid cyle: Isocitrate + NAD+ --> alpha-ketogluarat + CO2 + NADH C6 --> C5 by isocitrate dehydrogenase   a-ketoglutarate + CoA+ NAD+ --> Succinyl COA + CO2 + NADH C5 --> C4 by a-ketogluarate dehydrogenase

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