Laboratory Animal Science (Fach) / Genetics (Lektion)
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- Aim of lab animal breeding Standardizing the genetic influenceson the target characters inanimal experiments
- Target character groups Monogenic: The phenotype is caused by a single gene or a few genes;the environment does not matter significantly Polygenic The phenotype is caused by a (more or less large) number of genes; environmental ...
- Define Heritability Coefficient h² Relation between the genetic variance and the total varianceof a given characterThe coefficient value differs theoretically between0% (no genetic influence) and100% (monogenetic inheritance, no environmental ...
- The three breeding strategies Maximum homozygosity --> Inbreeding Repeatable heterozygosity --> Cross-Breeding Steady heterozygosity --> Outbreeding
- Concept, definition and characteristics of inbred ... Concept: Generation and preservation of genetic homozygosityDefinition: A minimum of 20 consecutive generations of brother x sister matingFor experimental use animals of F>>50 isrecommendedCharacteristics: ...
- Concept, definition and characteristics of outbreed ... Concept: Preservation of an established genetic variabilityDefinition: Closed breeding colony with minimized increase of inbreeding by application of rotation systems-Targets: the genetic pool of a stock ...