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Laboratory Animal Science (Fach) / Legislation (Lektion)
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- Name national and international authorities on animal experiments International legislation: Directive 2010/63/EU of the European Parliament and of theCouncil on the protection of animals used for scientific purposes - National legislations: German Animal Welfare Act: Art. 1 (subject matter and scope), Art 4 (3Rs), Art 13 (choice of methods) Animal Welfare - Laboratory Animal by Ordinance Versuchstiermeldeverordnung
- Which requisites must be fulfilled? every experiment must be justified, precisely described, and then authorized by theanimal welfare authorities before any animals become involved in a scientific project - the expected scientific and medical benefits of every animal experiment must be weighedagainst the estimated degree of suffering that the animals will experience - it is necessary before any experiment to undertake a comprehensive literature review tomake sure the experiment has not already been conducted elsewhere and wouldtherefore be unnecessary - three Rs must be adhered - all experiments are logged, and the number of animals used is reported annually
- name and explain the three Rs replacement: substitution of conscious living by insentient material --> in vitro and on silico approaches, these are the final goals of Directive 2010 EU --> cell culture/organoids/lab on a chip/artificial organs to practice reduction: decrease number of animals used based on appropriate and standardised statistical methods refinement: decrease incidence and severity of inhumane procedures -->meet biological needs of animals --> update and optimize experimental methods