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MolBio (Fach) / Mitosis + Cytokinesis (Lektion)
- Phases of Mitosis Prophase Prometaphase Metaphase Anaphase Telophase
- Prophase CCCNNHHM Condensins coil chromosoms in compact form Cohesins forms ring that hold sister chromatids together Centrosome moves to the cells poles (mediated by PLKs and Aurora A kinase) nuclear membrane breaks down (is packed into small vesicles) nucleolus disintegrates H1 histone phosphorylation and attachment of condensins is mediated by CDK1 H3 histone phosphorylation is mediated bei Aurora B kinase mitotic spindle starts to form
- Prometaphase Spindle fibres bind to kinetochor chromosomes migrate to metaphase plate
- Anaphase sister chromatid separation, breakdown of cohesins seperated sister chromatids = daughter chromosoms
- Telophase chromosomes arrive at cell poles mitotic spindle disassembles vesicles (with nuclear membrane) assemble around the chromosomes Phosphatases dephosphorylate lamins -leads to formation of new nuclear membrane
- Metaphase lined up chromosomes mitotic spindle checkpoint can be activated (in case of mitotic spindle assembly error) mediated by: -Anaphase-promoting complex/cyclosome (APC/C) -cyclin A & B
- Cytokinesis split into two identical daugther cells start signal = dephosphorylation cleavage furrow is formed by contractile ring of actin + myosin
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