1) affect and behavioral disorders show an increase in prevalence (e.g., major depressive disorder changes prevalence from 5% to 10% over early adolescence); most disorders have onset during adolescence

2) the manifestation of psychopathology changes (e.g., due to changes in cognitive capabilities hopelessness becomes more central in depression; anti-social behavior becomes more connected to criminal activity)

3) gender differences in prevalence rates intensify concerning affective disorder, but decrease in behavioral disorders.

4) some disorders show remarkable historical upward trends in prevalence, such as eating disorders, risk-taking behavior, and suicide