Zone I – periportal zone:- Viral hepatitis- Toxins (eg, cocaine)

Zone II – intermediate zone:- Yellow fever

Zone III – pericentral vein (centrilobular) zone:- Affected 1^st by ischemia- High concentration of cytochrome P-450- Most sensitive to metabolic toxins (eg, ethanol, CCl4, halothane, rifampin)ƒ - Alcoholic hepatitis