- Age of onset: 60-80 years- More common in African Americans

Risk factors: Smoking, obesity, high alcohol consumption, diet high in red meat, male gender, African American, age >65 years; diabetes, chronic pancreatits, liver cirrhosis; family history (BRCA2 mutation, PRSS1 gene mutation, Peutz-Jeghers syndrome)

Clinical presentation:- Nausea, vomiting, fatigue, weight loss, midepigastric pain- Trousseau sign (Thrombophlebitis migrans)- Courvoisier sign: Nontender, palpable gallbladder- Jaundice, darker urine, lighter stools, pruritus- Impaired glucose tolerance

Location:- Pancreatic head: 75% of cases- Pancreatic body: 15–20% of cases- Pancreatic tail: 5–10% of cases

Types:- Pancreatic exocrine tumors (95%): → Ductal adenocarcinoma→ Acinar adenocarcinoma → Cystadenocarcinoma- Pancreatic endocrine tumors (Neuroendocrine tumors, < 5% of tumors)→ Insulinomas (result in hypoglycemia)→ Gastrinomas→ Vasoactive intestinal peptide-producing tumors (VIPomas), pancreatic polypeptide-secreting endocrine tumors of the pancreas, glucagonomas, somatostatinomas

- Lab functions: ↑ Amylase, lipase, CA 19-9, CEA- Staging: (1) < 2 cm, (2) >2 cm, (3) invasing neighboring tissue, (4) metatatic

Treatment: (Neo)adjuvant chemotherapy, surgery