Pathologie (Fach) / Leber (Lektion)
- Most often in young women- Associated with HLA-DR3 and DR4, Hashimoto's thyroiditis, Grave's disease
Symptoms:Nonspecific symptoms: Fatigue, abdominal pain, weight loss- Signs of acute liver failure (∼ ⅓ of patients): Jaundice, RUQ pain, fever- Hepatosplenomegaly- ↑ transaminases (ALT > AST)
Type 1: 80% of cases- Anti-neuclear-antibodies (ANAs)- Anti-smooth-muscle antibodies (ASMA)- ↓ Albumin, ↑ Prothrombin time
Type 2: - Anti-LKM-1 (liver kidney microsome-1), anti-LC (liver cytosol-1), anti-SLA (soluble liver antigen)- Often young women
Differential diagnoses:- Viral hepatitis (e.g., hepatitis C)- Primary sclerosing cholangitis- Primary biliary cirrhosis- Alcohol-related hepatoxicity
Therapie:- Initial therapy: combination of prednisone and azathioprine- Maintenance therapy: azathioprine or prednisolone
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