Often due to organophosphages, such as parathion, that irreversible inhibit AChE.

- Diarrhea- Urination- Miosis- Bradycardia- Emesis- Lacrimation, salivation- Sweating- BronchospasmMay lead to respiratory failure if untreated.

Organophosphates are often components of insecticides; poisoning usually seen in farmers.

Antidote – atropine (competitive inhibitor) + pralidoxime (regenerates AChE if given early)