CRH: ↑ ACTH, MSH, β-endorphin- ↓ in chronic exogenous steroid use

Dopamine: ↓ prolactin, TSH- Dopamine antagonists (eg, antipsychotics) can cause galactorrhea due to hyperprolactinemia

GHRH: ↑ GH- Analog (tesamorelin) used to treat HIV-associated lipodystrophy

GnRH: ↑ FSH, LH- Suppressed by hyperprolactinemia- Tonic GnRH suppresses HPG axis- Pulsatile GnRH leads to puberty, fertility

MSH: ↑ melanogenesis by melanocytes- Causes hyperpigmentation in Cushing disease, as MSH and ACTH share the same precursor molecule, proopiomelanocortin.

Prolactin: ↓ GnRH- Pituitary prolactinoma → amenorrhea, osteoporosis, hypogonadism, galactorrhea

Somatostatin: ↓ GH, TSH

TRH: ↑ TSH, prolactin- ↑ TSH (eg, in 1°/2° hypothyroidism) may increase prolactin secretion → galactorrhea