A vascular proliferative disease that has been attributed to a herpesvirus HHV-8.

History/PE:- Presents with multiple red to violaceous macules, papules, or nodules that can progress to plaques on the lower limbs, back, face, mouth, and genitalia.- Plaques can also be found in the GI tract and lung.- HIV-associated KS is an aggressive form of the disease, it remains the most common HIV-associated malignancy.

Diagnosis: History, clinical impression, and histology.

Treatment: - Start HAART therapy- Small local lesions can be treated with radiation or cryotherapy- Widespread or internal disease is treated with systemic chemotherapy (doxorubicin, paclitaxel, or IFN-α).