Flecainide, Propafenone (Can I have fries, please?)

- Significantly prolongs ERP in AV node and accessory bypass tracts.- No effect on ERP in Purkinje and ventricular tissue.- Minimal effect on AP duration. (Ia ↑, Ib ↓, Ic –)

Clinical use:- SVTs, including atrial fibrillation.- Only as a last resort in refractory VT.

Adverse effects:- Proarrhythmic, especially post-MI (Ic is contraindicated in structural and ischemic heart disease)