Fusion protein (decoy receptor for TNF-α + IgG Fc) produced by recombinant DNA.

Clinical use:- Rheumatoid arthritis- Psoriasis- Ankylosing spondylitis

Adverse effects: Predisposition to infection, including reactivation of latent TB, since TNF is important in granuloma formation and stabilization. Can also lead to drug-induced lupus.