USMLE (Fach) / Biochemistry - Genetics (Lektion)
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Sickle cell anemia
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- substitution of valine for glutamate in Hb
- severe pain in the bones, abdomen, chest
- hemolytic problems
- episodes of vaso-occlusive pain lasting approx. 1 week
- can be resolved in electrophoresis (one negative charge less from glutamate)
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