Pathologie (Fach) / Muskuloskeletal (Lektion)
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Chondrosarcoma
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Malignant tumor arising from mesenchymal cells that produce cartilage.- Age: usually > 50 years- M > F
Symptoms:- Deep, dull pain (worsens at night, insidious progression over months to years)- Local swelling
Location: Medulla of pelvis and central skeleton
Diagnostics:- X-ray or CT → Osteolysis with moth-eaten appearance→ Calcifications (rings and arcs calcification, popcorn calcification)→ Endosteal scalloping and cortical breach with infiltration of soft tissue- MRI: rim-like contrast enhancement- Biopsy: Lobulated appearance (hyaline cartilage nodules with peripheral calcification )
Treatment:- Surgery (definitive resection) + chemotherapy and radiation therapy
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