USMLE (Fach) / Biochemistry - Molecular, Cellular, Techniques (Lektion)
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Mismatch repair
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Single strand DNA repair
- Fixes DNA copy errors
- Newly synthesized strand is recognized, mismatched nucleotides are removed, and the gap is filled and resealed.- Occurs predominantly in S phase of cell cycle.
Defective in Lynch syndrome (hereditary nonpolyposis colorectal cancer, HNPCC).
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