USMLE (Fach) / Biochemistry - Molecular, Cellular, Techniques (Lektion)
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Base excision repair
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Single strand DNA repair
- Important repair of spontaneous/toxic deamination.
- Base-specific glycosylase removes altered base and creates AP (apurinic/apyrimidinic) site.- One or more nucleotides are removed by AP-endonuclease, which cleaves the 5' end. - Lyase cleaves the 3' end. - DNA polymerase-β fills the gap and DNA ligase seals it.- Occurs throughout cell cycle
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