USMLE (Fach) / Biochemistry - Molecular, Cellular, Techniques (Lektion)
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Nucleotides
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Nucleoside = base + (deoxy)riboseNucleotide = base + (deoxy)ribose + phosphate; linked by 3'-5' phosphodiester bond.
5' end of incoming nucleotide bears the triphosphate (energy source for the bond).Triphosphate bond is target of 3' hydroxyl attack.
Purines: A, GPyrimidines: C, T, U
Deamination of cytosine forms uracil.Methylation of uracil makes thymine.Deamination of 5-methylcytosine forms thymine.
Deamination of adenine forms hypoxanthine.Deamination of guanine forms xanthine.
Amino acids necessary for purine synthesis: glycine, aspartate, glutamine.Pyrimidine out of carbamoyl phosphate, aspartate.
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