Inhibit NF-κB. Suppress both B- and T-cell function by ↓ transcription of many cytokines.Induce T cell apoptosis.

Use:- Many autoimmune and inflammatory disorders- Adrenal insufficiency- Asthma- CLL, non-Hodgkin lymphoma

Toxicity:- Cushing syndrome- Osteoporosis- Hyperglycemia- Diabetes- Amenorrhea- Adrenocortical atrophy- Peptic ulcers- Psychosis- Cataracts- Avascular necrosis (femoral head)

- Demargination of WBCs causes artificial leukocytosis. - Adrenal insufficiency may develop if drug is stopped abruptly after chronic use.