USMLE (Fach) / Pharmacology (Lektion)

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Measurement of drug safety.

Therapeutic index (TI) = TD50/ED50 = median toxic dose/median effective dose

Therapeutic window – dosage range than can safely and effectively treat disease.

Safer drugs have higher TI values. Drugs with lower TI values frequently require monitoring (eg, warfarin, theophylline, digoxin, lithium).

LD50 (lethal median dose) often replaces TD50 in animal studies.

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