USMLE (Fach) / Pharmacology (Lektion)
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Half-life (t1/2)
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Part of the pharmacokinetics.
The time required to change the amount of drug in the body by 1/2 during elimination.
In first-order kinetics, a drug infused at a constant rate takes 4-5 half-lives to reach steady state. It takes 3.3 half-lives to reach 90% of the steady-state level.
t1/2 = (0.7 x Vd)/CL in first-order elimination
1 half-life: 50% remaining2 half-lives: 25% remaining3 half-lives: 12.5% remaining4 half-lives: 6.25% remaining
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