Ibuprofen, naproxen, indomethacin, ketorolac, diclofenac, meloxicam, piroxicam

Reversibly inhibit cyclooxygenase (both COX-1 and COX-2). Block prostaglandin synthesis.

Clinical use: Antipyretic, analgesic, anti-inflammatory- Indomethacin is used to close PDA.

Adverse effects:- Interstitial nephritis- Gastric ulcer (prostaglandins protect gastric mucosa)- Renal ischemia (prostaglandins vasodilate afferent arteriole)- Aplastic anemia