Interleukin-1: Causes fever, acute inflammation. Activates endothelium to express adhesion molecules. Induces chemokine secretion to recruit WBCs. Also known as osteoclast-activating factor.

Interleukin-6: Causes fever and stimulates production of acute-phase proteins.

Interleukin-8: Major chemotactic factor for neutrophils.

Interleukin-12: Induces differentiation of T cells into Th1 cells. Activates NK cells.

Tumor necrosis factor-α: Activates endothelium. Causes WBC recuitment, vascular leak.