USMLE (Fach) / Pharmacology - Renal (Lektion)

Vorderseite Spironolactone, Eplerenone
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Competitive aldosterone receptor antagonists in cortical collecting tubule

Clinical use:
- Hyperaldosteronism
- K+ depletion
- HF
- Hepatic ascites (spironolactone)
- Antiandrogen

Adverse effects:
- Hyperkalemia (can lead to arrhythmias)
- Endocrine effects with spironolactone (eg, gynecomastia, antiandrogen effects)

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