USMLE (Fach) / Pharmacology - Renal (Lektion)
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Spironolactone, Eplerenone
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Competitive aldosterone receptor antagonists in cortical collecting tubule
Clinical use:- Hyperaldosteronism- K+ depletion- HF- Hepatic ascites (spironolactone)- Antiandrogen
Adverse effects:- Hyperkalemia (can lead to arrhythmias)- Endocrine effects with spironolactone (eg, gynecomastia, antiandrogen effects)
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