USMLE (Fach) / Pharmacology - Renal (Lektion)

Vorderseite Furosemide, bumetanide, torsemide
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Sulfonamide loop diuretics. Inhibit cotransport system (Na+/K+/2Cl-) of thick ascending limb of loop of Henle. Abolish hypertonicity of medulla, preventing concentration of urine.
Stimulate PGE release (vasodilatory effect on afferent arteriole); inhibited by NSAIDs.
↑ Ca2+ excretion.

Use:
- Edematous states (HF, cirrhosis, nephrotic syndrome, pulmonary edema)
- Hypertension
- Hypercalcemia

Adverse effects:
- Ototoxicity
- Hypokalemia
- Hypomagnesemia
- Dehydration
- Sulfa allergy
- Metabolic alkalosis
- Interstitial nephritis
- Gout

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