USMLE (Fach) / Pharmacology - Renal (Lektion)

Vorderseite Furosemide, bumetanide, torsemide
Rückseite

Sulfonamide loop diuretics. Inhibit cotransport system (Na+/K+/2Cl-) of thick ascending limb of loop of Henle. Abolish hypertonicity of medulla, preventing concentration of urine.Stimulate PGE release (vasodilatory effect on afferent arteriole); inhibited by NSAIDs.↑ Ca2+ excretion.

Use:- Edematous states (HF, cirrhosis, nephrotic syndrome, pulmonary edema)- Hypertension- Hypercalcemia

Adverse effects:- Ototoxicity- Hypokalemia- Hypomagnesemia- Dehydration- Sulfa allergy- Metabolic alkalosis- Interstitial nephritis- Gout

Diese Karteikarte wurde von estoffel erstellt.