USMLE (Fach) / Pharmacology - Renal (Lektion)
Vorderseite
Furosemide, bumetanide, torsemide
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Sulfonamide loop diuretics. Inhibit cotransport system (Na+/K+/2Cl-) of thick ascending limb of loop of Henle. Abolish hypertonicity of medulla, preventing concentration of urine.Stimulate PGE release (vasodilatory effect on afferent arteriole); inhibited by NSAIDs.↑ Ca2+ excretion.
Use:- Edematous states (HF, cirrhosis, nephrotic syndrome, pulmonary edema)- Hypertension- Hypercalcemia
Adverse effects:- Ototoxicity- Hypokalemia- Hypomagnesemia- Dehydration- Sulfa allergy- Metabolic alkalosis- Interstitial nephritis- Gout
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