USMLE (Fach) / Biochemistry - Molecular, Cellular, Techniques (Lektion)

Vorderseite Elastin
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Stretchy protein within skin, lungs, large arteries, elastic ligaments, vocal cords, ligamenta flava (connect vertebrae → relaxed and stretched conformations).- Rich in nonhydroxylated proline, glycine, and lysine residues (vs hydroxylated residues of collagen).- Tropoelastin with fibrillin scaffolding.- Cross-linking takes place extracellularly and gives elastin its elastic properties.

- Broken down by elastase, which is normally inhibited by α1-antitrypsin.- α1-Antitrypsin deficiency results in unopposed elastase activity, which can cause emphysema.

- Changes with aging: ↓ dermal collagen and elastin, ↓ synthesis of collagin fibrils; crosslinking remains normal.

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