USMLE (Fach) / Biochemistry - Molecular, Cellular, Techniques (Lektion)

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Membrane-enclosed organelle involved in:- β-oxidation of very-long-chain fatty acids (VLCFA)- α-oxidation (strictly peroxisomal process)- Catabolism of branched-chain fatty acids, amino acids, and ethanol- Synthesis of cholesterol, bile acids, plasmalogens (important membrane phospholipid, especially in white matter of brain)

Peroxismal disorders commonly lead to neurologic disease due to deficits in synthesis plasmalogens, important phospholipids in myelin.

Peroxismal diseases include Zellweger syndrome, Refsum disease, and adrenoleukodystrophy.

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